Congratulations to Merve Keles obtaining his PhD with the thesis “Secreted long non-coding RNAs Gadlor1 and Gadlor2 act as mediators of cardiac remodelling during pressure overload”, where TATAA’s RNA spikes were successfully used as exogeneous controls.
Oligodendrocytes (OL) have been for decades considered a passive, homogenous population of cells that provide support to neurons, and show a limited response to pathological stimuli. This view has been dramatically changed.
Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host stroma. To understand why functional respiration is crucial for tumorigenesis, we used time-resolved analysis of tumor formation by mtDNA-depleted cells and genetic manipulations of OXPHOS.