Next Generation Sequencing
Targeted gene panels
Targeted gene panels analyze the expression of specific genes or regions associated with a particular disease or drug response. This approach is highly focused and efficient for clinical trials where specific genetic variants are of primary interest.
Target NGS
The targeted panels are customized to focus on disease-related genes or drug response pathways, using various biological samples based on your specific needs.
Identify mutations in key genes linked to specific diseases.
Detect actionable mutations for treatment response and disease progression.
Group patients based on mutations in selected therapeutic genes.
Detect known resistance mutations during treatment for timely intervention.
Identify mutations associated with adverse drug reactions or toxicity.
Investigate known disease-causing mutations in patient populations.
PCR ASSAYS AT TATAA
TATAA Biocenter specializes in developing and validating quantitative nucleic acid analysis (qPCR and dPCR) for bioanalysis, adhering to regulatory requirements for different phases. Our services encompass fit-for-purpose assays to full Good Laboratory Practice (GLP) and Good Clinical Laboratory Practice (GCLP) compliant assays. We ensure GLP accreditation for preclinical and GCLP compliance for clinical samples, meeting FDA and EMA standards.
Our core expertise is quantifying low-copy RNA and DNA in intricate biological samples. Our services encompass consultation on sampling, storage, transportation, experimental planning, instrument selection, and reagent recommendations. We excel in extractions from diverse tissue types, biofluids, and various sampling tools.
Targeted NGS
Library preparation
IDT xGen DNA Library Prep Kit EZ with UDIs, combined with xGen Exome Hyb Panel v2
Recommended sample input
- Fresh frozen cells or tissue
- EDTA whole blood or PAXgene DNA tubes
- High quality FFPE (IDT DNA Integrity score > 1.0)
Recommended DNA input
Range: 0.1 ng – 1 ug
Standard input: 100ng
Recommended sequencing
Paired-end sequencing
Deliverables
Quality-controlled data
Fastq files
Study report
About us
The power of our approach
Committed to quality, innovation, and fostering strong client relationships, we serve as your trusted partner to accelerate drug development. As a contract research organization, our mission is to push the boundaries of science and technology to generate accurate and reproducible data that shortens time-to-market.
Regulated laboratory environment
We are GLP accredited for qPCR, dPCR, and molecular biology, GCLP compliant, and ISO/IEC 17025 accredited. Our facility features a strict sample management process, a fully integrated LIMS system, backup for all vital systems, temperature and humidity control, and robust IT security.
Purpose-built PCR laboratory
Our purpose-built laboratory in Gothenburg, Sweden, is specifically designed for PCR. It has controlled air pressure, temporal separation, and biosafety cabinets to minimize contamination risk. This setup enables us to achieve the highest sensitivity and robustness required for validated assays. The lab is equipped with market-leading PCR and NGS instruments and advanced liquid handling systems.
Pioneers in assay development and validation
We are a team of 45 employees, with scientists at the forefront of assay development, optimization, and validation. Our team has co-authored key publications in the field, including Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug Development (AAPS J. 2024) and The MIQE Guidelines for qPCR and dPCR.
Flexible, client-centered solutions
We work closely with our clients to find tailored solutions, offering flexibility in sample types, test items, sample volume, and scalability. We prioritize transparency and proactive communication throughout each project, ensuring our clients are continuously updated on the progress.
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Let's explore how we can support your drug development program.
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