Bioanalytical CRO
Immunology and inflammatory disease
We provide advanced molecular services to help understand the molecular landscape in immunology and inflammatory disease drug development.
| Immunological and inflammatory diseases | ||
| Technique | Capability | Analytical outcome |
| qPCR | •Biomarker quantification, | Quantify expression of key immune and inflammatory biomarkers, monitor gene expression changes. |
| •Gene expression analysis | ||
| dPCR | •Low-level biomarker detection | Highly sensitive quantification of low-abundance inflammatory biomarkers and rare immune gene variants. |
| •Rare variant detection | ||
| DNA-seq | •Mutation detection | Detect mutations, copy number variation, and structural variants linked to immune dysregulation. |
| •Genomic variations associated with autoimmune disorders | ||
| RNA-seq | •Gene expression analysis | Insights into immune-related gene expression and monitor inflammation-related gene modulation. |
| •Immune response monitoring | ||
| •Inflammatory pathway modulation | ||
| Immunoprofiling | •Immune response monitoring | Measures levels of inflammatory cytokines, such as TNF-alpha, IL-6, and IL-1β. |
| •Inflammatory cytokine detection | ||
| TCR/BCR seq | •Immune repertoire analysis | Track T-cell and B-cell receptor diversity, clonal expansion, and immune response. |
| •Clonal expansion | ||
| •Autoimmune monitoring | ||
Services
Solutions for complex biological challenges
We offer a broad range of tailored commissioned services for drug development programs. With over two decades of expertise in nucleic acid analysis and sample preparation, we optimize workflows by assessing sample quality, validating performance, and analyzing clinical biomarkers using leading, well-matched technologies.
Extraction
Accurate quantification begins with precise extraction
Comprehensive extraction across all sample types and test items
We have extensive experience extracting nucleic acids from various biological samples, including tissues, biofluids, swabs, excreta, secreta, fresh frozen, or FFPE-fixed.
Our expertise covers the extraction of different types of nucleic acids, including DNA, cfDNA, short RNAs (miRNA, siRNA, and more), messenger RNA, and ASOs with diverse modifications and chemical properties.
We consistently include spike-ins to ensure efficient extraction, optimal quality for downstream applications, and the removal of inhibitory agents. Our goal is the accurate quantification of the target molecule, where precise, high-quality extraction is essential for achieving both accuracy and precision.
Automated workflows
Enhance precision and productivity with automation
Most pipetting steps can be fully automated with our advanced liquid handling platforms.
Automation standardizes processes, ensuring consistent and precise results across experiments. By automating repetitive tasks such as sample handling and assay preparation, we can manage a higher volume of samples, accelerate project timelines, and easily scale to accommodate studies ranging from preclinical to large clinical cohorts. Our automated systems are fully integrated with our LIMS, ensuring accurate sample tracking, data traceability, and regulatory compliance.
why work with tataa?
The Power of Our Approach
Committed to quality, innovation, and fostering strong client relationships, we serve as your trusted partner to accelerate drug development. As a contract research organization, our mission is to push the boundaries of science and technology to generate accurate and reproducible data that shortens time-to-market.
Custom solutions
We customize solutions based on sample type(s), number of test items, sample volume, level of automation, regulatory requirements, and context of use. Our flexible approach focuses on delivering quality data to support your decision-making.
Nucleic acid experts
As a niche CRO, we specialize in nucleic acid extraction, assay development, and validation of nucleic acid quantification. With our extensive experience, we deliver expert solutions that accelerate method development and provide reliable, high-quality data you can trust.
Compliance
We are GLP-accredited by SWEDAC, GCLP-compliant, and ISO/IEC 17025 accredited, ensuring a robust quality management system. This includes secure data storage, power backup, precise monitoring of humidity and temperature, rigorous sample management processes, full traceability, and a team of skilled, qualified personnel.
Infrastructure
We operate in a state-of-the-art, purpose-built laboratory with dedicated areas, controlled air pressure, and optimized workflows to minimize contamination risks. Our facility is equipped with industry-leading qPCR, dPCR, and NGS platforms and advanced automated liquid handling systems for automated sample transfer, assay mixing, dilution, extraction, and library preparation.
contact us
Let's explore how we can support your drug development program
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