RNA Sequencing
Our RNA sequencing solutions provide comprehensive transcriptomic analysis options for a wide variety of sample inputs and a choice of methods to suit your needs.
Identify biomarkers, reveal therapeutic targets, analyze drug response and resistance, elucidate mechanisms of action, assess immune response, and explore other applications.
Transcriptomics
RNA-seq solutions
We support drug development from early discovery through clinical trials with tailored sequencing solutions customized to the biological sample, project goals, and regulatory requirements. Our services encompass everything from sample collection guidance to advanced bioinformatics analysis.
Total RNA-Seq
Captures all RNA species in a sample, including mRNA, tRNA, lncRNA, and other non-coding RNAs. Ribosomal RNA is usually depleted before sequencing to focus on other RNA types.
mRNA-Seq
Targets only messenger RNA (mRNA) by enriching poly-A tails, thereby isolating mature, coding RNA. Data reflects gene expression by sequencing exonic regions.
3’-mRNA-Seq
It focuses on sequencing the 3’-ends of polyadenylated transcripts. Cost-effective and suitable for degraded samples, providing gene-level expression quantification without full transcript coverage.
Small RNA-Seq
Targets small RNA species (typically 18-30 nucleotides), such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and piwi-interacting RNAs (piRNAs). This type of sequencing can capture RNA-mediated gene regulation.
TCR/BCR-Seq
Study the diversity of T-cell and B-cell populations, revealing how specific clones expand or contract in response to therapies or diseases on RNA or DNA levels.
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Automated workflows
Enhance precision and productivity with automation
Most pipetting steps can be fully automated with our advanced liquid handling platforms.
Automation standardizes processes and minimizes the risk of human error, ensuring consistent and precise results across experiments. By automating repetitive tasks such as sample handling and assay preparation, we can manage a higher volume of samples, accelerate project timelines, and easily scale to accommodate studies ranging from preclinical to large clinical cohorts. Our automated systems are fully integrated with our LIMS, ensuring accurate sample tracking, data traceability, and regulatory compliance while reducing the risk of sample mix-ups.
Extraction
Accurate quantification begins with precise extraction
Comprehensive extraction across all sample types and test items
We have extensive experience extracting nucleic acids from various biological samples, including tissues, biofluids, swabs, excreta, secreta fresh frozen, or FFPE-fixed.
Our expertise covers the extraction of different types of nucleic acids, including DNA, cfDNA, short RNAs (miRNA, siRNA, and more), messenger RNA, and ASOs with diverse modifications and chemical properties.
We consistently include spike-ins to ensure efficient extraction, optimal quality for downstream applications, and the removal of inhibitory agents. Our goal is the accurate quantification of the target molecule, where precise, high-quality extraction is essential for achieving both accuracy and precision.
Services
Solutions for complex biological challenges
We offer a broad range of tailored commissioned services for drug development programs. With over two decades of expertise in nucleic acid analysis and sample preparation, we optimize workflows by assessing sample quality, validating performance, and analyzing clinical biomarkers using leading, well-matched technologies.
About us
The power of our approach
Committed to quality, innovation, and fostering strong client relationships, we serve as your trusted partner to accelerate drug development. As a contract research organization, our mission is to push the boundaries of science and technology to generate accurate and reproducible data that shortens time-to-market.
Regulated laboratory environment
We are GLP accredited for qPCR, dPCR, and molecular biology, GCLP compliant, and ISO/IEC 17025 accredited. Our facility features a strict sample management process, a fully integrated LIMS system, backup for all vital systems, temperature and humidity control, and robust IT security.
Purpose-built PCR laboratory
Our purpose-built laboratory in Gothenburg, Sweden, is specifically designed for PCR. It has controlled air pressure, temporal separation, and biosafety cabinets to minimize contamination risk. This setup enables us to achieve the highest sensitivity and robustness required for validated assays. The lab is equipped with market-leading PCR and NGS instruments and advanced liquid handling systems.
Pioneers in assay development and validation
We are a team of 45 employees, with scientists at the forefront of assay development, optimization, and validation. Our team has co-authored key publications in the field, including Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug Development (AAPS J. 2024) and The MIQE Guidelines for qPCR and dPCR.
Flexible, client-centered solutions
We work closely with our clients to find tailored solutions, offering flexibility in sample types, test items, sample volume, and scalability. We prioritize transparency and proactive communication throughout each project, ensuring our clients are continuously updated on the progress.
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Let's explore how we can support your drug development program.
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