Molecular analysis serviceS

Solutions for complex biological challenges

We are a leading molecular analysis services CRO in genomics, transcriptomics, proteomics, microbiome and single cell analysis.

We help advance drug development, scientific research and clinical trials.

How we do it

We are pioneers in a wide range of molecular analysis - including PCR and NGS.

We custom design our bioanalytical services to suit your research needs. 

We have more than two decades of knowledge and experience in nucleic acid analysis and sample preparation.

We optimize entire workflows by assessing sample quality, validating performance, and analyzing single or multiple biomarkers with the best technology, including our own. 

We also support data analysis and modeling.

our Technologies & Applications

Experts in nucleic acid sample preparation and bioanalyses

  • Significant experience working with a wide range of challenging sample types, from a variety of organisms.
  • We design bioanalysis assays, optimize and validate workflows, assess samples, and support with data and result analysis, interpretation and modelling.
  • We offer complete bioanalytical services – spanning project planning to qPCR data analysis – as well as execution of discrete project parts that require expertise and/or instrumentation.
what we offer

We deliver expertise, innovation and quality to molecular analysis

Expertise

We have decades of experience in PCR & NGS, multiple supported drugs, trainings and tech transfers.

Innovation

Our R&D department, develops proprietary methods and assays, and are early adopters of new technologies.

Quality

Our GLP-ready, state-of-the-art laboratory supports development and validation of quality standards.

 

Bioanalytical Services

Technology & Applications

Genomics & Epigenomics

qPCR, dPCR

Assay design, transfer, optimization, validation
Genotyping
SNP profiling
Rare mutation
Residual DNA
Copy number variation
Absolute quantification

NGS

Whole genome sequencing (WGS)
16S and ITS Sequencing
Amplicon sequencing
Exome sequencing
Chromatin IP (ChIP) sequencing
Methylation analysis
Hybridisation capture

Transcriptomics

qPCR, dPCR

Assay design, transfer, optimization, validation
Single cell
Gene expression
Pharmacodynamics

Two Tailed RT-qPCR

miRNA profiling
Genotyping
Customized assays and solutions to address your particular challenge

NGS

Small RNA Sequencing
mRNA Sequencing
Full transcriptome
Gene Expression Profiling by 3’mRNA
Single cell
Extraction-free miRNA analysis
Adaptive Immune Repertoire profiling

Proteomics

Olink (qPCR and NGS)

Protein expression profiling

Technology & Applications

Microbiome

qPCR, dPCR

Viability PCR
Pathogen detection

NGS

16S rRNA sequencing

Gene Therapy

qPCR, dPCR

Drug exposure, biodistribution and shedding
mRNA quantitation and cleavage
siRNA PK-PD

NGS

Degradome analysis
Off-target effect

Biomolecules

Robotic liquid handling

Challenging samples
High-throughput aliquoting

Extraction

Genomic DNA, cf-DNA, total RNA, smallRNAs, cf-RNA, exosomes
Automated or manual

Processing

Quantity and quality testing of RNA, miRNA, DNA, and proteins
Normalization and cDNA synthesis
Library preparation and quality control

Biostatistics & Informatics

Integration and analysis of NGS and proteomics data

Additional Services

Validation of kits, reagents and instruments
Direct Blood Genotyping
Single cell profiling
Cell-free DNA analysis
Analysis of circulating tumor cells
Residual DNA analysis

Consulting

Experimental design
Sample collection and processing workflow
Customized solutions to address your particular challenge

Workflow

From sampling to results

Optimization and validation of laboratory analysis is important but not sufficient to ensure high quality results. Lippi et al (2011) estimated that 60% to 70% of bioanalytical problems can be attributed to mishandling procedures during sample collection, transport, preparation and storage. 

We advise on sampling procedures including sampling tubes, handling of samples, transport and storage conditions, as well as quality assessment of representative samples.

bioanalytical services
TATAA’s Unique Offerings

Experiment design and optimization

We help you design your experiments and optimize setup to reduce costs and improve power.

Proper experiment design can save you substantial time and money. Before starting any large study, you should perform a small pilot to estimate variance contributions from the different experimental. Defective steps can be identified and improved. Once all steps are optimized, you can best arrange the nesting of the experiment by determining at which steps to perform technical replicates to obtain the highest data quality within your budget.

Once a standard operating procedure is in place, you can estimate the number of subjects to be recruited for the study based on the total technical variance of the experiment.

Custom bioanalytical services

Expert advice and
consulting

Consulting and advice

We provide consulting and advice on sampling, sample extraction, storage, transportation, experiment design, instruments, reagents and methods, primer design, data analysis and statistics. We can also help you with all your nucleic acid analyses needs.

Priority consulting

Customers with an active consulting account benefit from timely and cost-effective support for real-time PCR-related questions. As a Priority Customer you can contact us whenever you need support, and we will put you in contact with the scientist at TATAA that can best answer your question.

TATAA Biocenter offers bioanalytical services

Sample quality matters.

Pre-analytical steps are so pivotal that the European Union sponsored the SPIDIA-SPIDIA4P initiative to standardize and improve the generic pre-analytical tools and procedures for in vitro diagnostics. TATAA has been a member of this consortium since 2008.

Molecular in vitro diagnostics have enabled significant progress in medicine. Further progress is expected through new technologies that analyze signatures of nucleic acids, proteins, and metabolites in human tissues and body fluids. However, molecular profiles can change drastically during primary sample collection, transport, storage, and processing – jeopardizing the reliability of diagnostic outcomes and research.

Therefore, standardizing the entire diagnostic workflow, from sample collection to analytical measurement, is needed to ensure reproducibility of results and improve clinical decision-making and healthcare.

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