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We are a leading molecular analysis services CRO in genomics, transcriptomics, proteomics, microbiome and single cell analysis.
We help advance drug development, scientific research and clinical trials.
We custom design our bioanalytical services to suit your research and academic needs.
We have more than 20 years of knowledge and experience in nucleic acid analysis and sample preparation.
We optimize entire workflows by assessing sample quality, validating performance, and analyzing single or multiple biomarkers with the best technology, including our own.
We also support data analysis and modeling.
Decades of experience in PCR & NGS, with multiple supported drugs, trainings and tech transfers.
We’ve developed proprietary methods and assays, and are early adopters of new technologies.
Our GLP-ready, state-of-the-art laboratory supports development and validation of quality standards.
Assay design, transfer, optimization, validation
Genotyping
SNP profiling
Rare mutation
Residual DNA
Copy number variation
Absolute quantification
Our services allow a variety of applications for analysis of the genome. We offer SNP profiling and rare mutation detection, copy number variation analysis, whole genome sequencing, de novo sequencing, whole exome sequencing, targeted sequencing, amplicon sequencing), and epigenome studies (Chromatin IP (ChIP) sequencing, methylation analysis).
Whole genome sequencing (WGS)
16S and ITS Sequencing
Amplicon sequencing
Exome sequencing
Chromatin IP (ChIP) sequencing
Methylation analysis
Hybridisation capture
Our services allow a variety of applications for analysis of the genome. We offer SNP profiling and rare mutation detection, copy number variation analysis, whole genome sequencing, de novo sequencing, whole exome sequencing, targeted sequencing, amplicon sequencing), and epigenome studies (Chromatin IP (ChIP) sequencing, methylation analysis).
Assay design, transfer, optimization, validation
Single cell
Gene expression
Pharmacodynamics
We offer several technologies and platforms for studying gene expression, from single genes to full transcriptomes, including miRNA. We study the transcriptome using qPCR, dPCR, and NGS, and offer a variety of unique technologies and platforms.
Contact UsmiRNA profiling
Genotyping
Customized assays and solutions to address your particular challenge
TATAA Biocenter researchers invented Two-Tailed RT-qPCR in 2017, which offers a superior solution for miRNA profiling. Instead of using a single binding probe, it uses two hemiprobes connected by a folded tether. Each hemiprobe binds to different stretches of the same microRNA. Binding is exceedingly specific, as the impact of a mismatch is much more profound in a short hemiprobe. The cDNA formed can then be PCR amplified using two sequence specific primers. SYBR or hydrolysis probes can be used for detection. High melting resolution analysis can be used for non-specific products detection.
Small RNA Sequencing
mRNA Sequencing
Full transcriptome
Gene Expression Profiling by 3’mRNA
Single cell
Extraction-free miRNA analysis
Adaptive Immune Repertoire profiling
Send us your pre-prepared libraries for sequencing or combine NGS sequencing with our other services (e.g., nucleic acid extraction, experimental design, advanced analysis, etc.) for a complete workflow.
Protein expression profiling
Our Olink Proteomics platforms generate high quality data even in highly multiplexed formats and their applications are enormous for powerful analysis of multivariate biomarker patterns.
Our Olink-qPCR based platform offers protein expression for disease-specific or biological pathways. Our Olink Explore 1536/384 platform measures 1,536 proteins with PEA technology and readout on NGS. One single system can perform1.3 million protein measurements per week. And requires less than 4µL sample to screen the entire library!
Partner with UsViability PCR
Pathogen detection
The number of viable and non-viable cells in a solution are quantified using an optimized workflow based on digital PCR.
16S rRNA sequencing
Our 16S rRNA sequencing offering allows for identification, classification and quantification of microbes and bacteria within complex biological mixtures
Drug exposure, biodistribution and shedding
mRNA quantitation and cleavage
siRNA PK-PD
Degradome analysis
Off-target effect
Challenging samples
High-throughput aliquoting
Using our Hamilton STAR and Nimbus robotic systems.
Genomic DNA, cf-DNA, total RNA, smallRNAs, cf-RNA, exosomes
Automated or manual
TATAA successfully processes sample types derived from a variety of organisms and tissues, including: yeast, plants, bacteria, human and animal tissues, cell pellets, cell cultures, cartilage pellets, bone, tumors, biopsies, saliva, formalin fixed paraffin embedded (FFPE) tissues, cervical samples, LMD samples, stem cells, single cells, process samples for residual DNA, etc
Quantity and quality testing of RNA, miRNA, DNA, and proteins
Normalization and cDNA synthesis
Library preparation and quality control
We have access to many methods and instruments for quantifying biomolecule amounts and testing samples for quality, integrity and purity. This provides the highest quality and reproducibility of protocols, which are essential for any downstream processing and analyses. Our systems require minute sample volumes (less than 2 µL), allowing you to maximize samples for further analyses. Our automated gel electrophoresis platforms make your analyses fast and highly cost efficient. Nucleic acids can also be quantified using NanoDrop ND-1000 as well as PicoGreen. RNA must be converted into cDNA with reverse transcription (RT) for real-time PCR analysis. Our experts, who laid the ground for all optimization protocols of reverse transcription, will provide you with the best method possible. To avoid variations in the amounts of sample used for the RT, a normalization of the RNA concentrations should be performed before the cDNA synthesis.
Integration and analysis of NGS and proteomics data
TATAA Biocenter can support your data analysis and help getting the most out of your data. Our expert statisticians can help identifying the most significant and distinctive reporter genes, the most stable reference genes, compare expression of genes in groups, test the significance of treatment, distinguish sample types and groups of genes based on multivariate expression profiles, and develop classification algorithms based on training samples to classify patient samples.
Validation of kits, reagents and instruments
Direct Blood Genotyping
Single cell profiling
Cell-free DNA analysis
Analysis of circulating tumor cells
Residual DNA analysis
Experimental design
Sample collection and processing workflow
Customized solutions to address your particular challenge
Optimization and validation of laboratory analysis is important but not sufficient to ensure high quality results. Lippi et al (2011) estimated that 60% to 70% of bioanalytical problems can be attributed to mishandling procedures during sample collection, transport, preparation and storage.
We advise on sampling procedures including sampling tubes, handling of samples, transport and storage conditions, as well as quality assessment of representative samples.
Proper experiment design can save you substantial time and money. Before starting any large study, you should perform a small pilot to estimate variance contributions from the different experimental. Defective steps can be identified and improved. Once all steps are optimized, you can best arrange the nesting of the experiment by determining at which steps to perform technical replicates to obtain the highest data quality within your budget.
Once a standard operating procedure is in place, you can estimate the number of subjects to be recruited for the study based on the total technical variance of the experiment.
We provide consulting and advice on sampling, sample extraction, storage, transportation, experiment design, instruments, reagents and methods, primer design, data analysis and statistics. We can also help you with all your nucleic acid analyses needs.
Customers with an active consulting account benefit from timely and cost-effective support for real-time PCR-related questions. As a Priority Customer you can contact us whenever you need support, and we will put you in contact with the scientist at TATAA that can best answer your question.
Molecular in vitro diagnostics have enabled significant progress in medicine. Further progress is expected through new technologies that analyze signatures of nucleic acids, proteins, and metabolites in human tissues and body fluids. However, molecular profiles can change drastically during primary sample collection, transport, storage, and processing – jeopardizing the reliability of diagnostic outcomes and research.
Therefore, standardizing the entire diagnostic workflow, from sample collection to analytical measurement, is needed to ensure reproducibility of results and improve clinical decision-making and healthcare.
TATAA Biocenter AB © 2023 All rights reserved
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