DNA, RNA, AND PROTEIN
Trusted provider of PCR and NGS
Nucleic acid experts
Our technologies
We optimize and validate the entire workflow, from raw tissue specimens to the final data, ensuring the highest quality results are delivered.
RNA-seq
We offer RNA sequencing solutions for total RNA and mRNA-seq analysis, as well as tag-based approaches like 3’-mRNA sequencing and small RNA-seq. These methods help identify biomarkers, reveal therapeutic targets, analyze drug response and resistance, elucidate mechanisms of action, assess immune response, and support various other applications.
DNA-seq
Through various DNA-seq applications, we simultaneously sequence the whole genome, exome, or targeted panels to reveal genetic variations, discover drug targets, understand disease mechanisms, stratify patients, and identify predictive or prognostic biomarkers, all at the DNA level.
qPCR/dPCR
We develop and validate dPCR/qPCR assays for biomarker quantification, biodistribution, shedding, and pharmacokinetics in cell and gene therapies. Offering high sensitivity for low-abundance targets across diverse sample types, we support all phases of drug development. Our validated PCR assays for short targets, including siRNA and miRNA, use the Two-Tailed PCR technology.
Olink proteomics
Olink’s high-throughput, highly multiplex proteomics platform enables the analysis of over 5,400 proteins, or smaller targeted panels, from small sample volumes. This makes it ideal for discovering and validating protein biomarkers associated with disease pathways, therapeutic responses, or safety concerns.
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TWO-Tailed PCR technology
Short RNA quantification with qPCR/dPCR
A TATAA Biocenter innovation that offers validated qPCR/dPCR workflows for siRNA, miRNA, ASOs, and other short nucleic acid targets.
PCR bioanalysis offers several advantages over other methods in speed and throughput; however, standard PCR is unsuitable for short targets due to its length. We have developed a two-tailed primer that enables the optimization, validation, and execution of PCR-based bioanalysis on any short target with high sensitivity and specificity.
Services
Solutions for complex biological challenges
We offer a broad range of tailored commissioned services for drug development programs. With over two decades of expertise in nucleic acid analysis and sample preparation, we optimize workflows by assessing sample quality, validating performance, and analyzing clinical biomarkers using leading, well-matched technologies.
Extraction
Accurate quantification begins with precise extraction
Comprehensive extraction across all sample types and test items
We have extensive experience extracting nucleic acids from various biological samples, including tissues, biofluids, swabs, excreta, secreta, fresh frozen, or FFPE-fixed.
Our expertise covers the extraction of different types of nucleic acids, including DNA, cfDNA, short RNAs (miRNA, siRNA, and more), messenger RNA, and ASOs with diverse modifications and chemical properties.
We consistently include spike-ins to ensure efficient extraction, optimal quality for downstream applications, and the removal of inhibitory agents. Our goal is the accurate quantification of the target molecule, where precise, high-quality extraction is essential for achieving both accuracy and precision.
Primer dimer test Primer-dimers can bias qPCR results, so a test for primer-dimers should be performed during assay development to ensure that only the target sequence is amplified and quantified. The effect of primer dimers Checking for primer dimers is
TCR sequencing TCR sequencing on DNA or RNA is used to understand anti-tumor immune responses and to track responses to infections, vaccinations, and immunotherapies. Our TCR sequencing services Ask a question What is a T-cell receptors (TCRs)? T-cell receptors (TCRs)
Pharmacokinetics (PK) in gene therapies Pharmacokinetics for genes introduced by gene therapies is more challenging than those of finished small molecules. Our custom assays for biodistribution, pharmacokinetics (PK), and shedding. Ask a question Pharmacokinetics (PK) in gene therapies Pharmacokinetics for
About us
The power of our approach
Committed to quality, innovation, and fostering strong client relationships, we serve as your trusted partner to accelerate drug development. As a contract research organization, our mission is to push the boundaries of science and technology to generate accurate and reproducible data that shortens time-to-market.
Regulated laboratory environment
We are GLP accredited for qPCR, dPCR, and molecular biology, GCLP compliant, and ISO/IEC 17025 accredited. Our facility features a strict sample management process, a fully integrated LIMS system, backup for all vital systems, temperature and humidity control, and robust IT security.
Purpose-built PCR laboratory
Our purpose-built laboratory in Gothenburg, Sweden, is specifically designed for PCR. It has controlled air pressure, temporal separation, and biosafety cabinets to minimize contamination risk. This setup enables us to achieve the highest sensitivity and robustness required for validated assays. The lab is equipped with market-leading PCR and NGS instruments and advanced liquid handling systems.
Pioneers in assay development and validation
We are a team of 45 employees, with scientists at the forefront of assay development, optimization, and validation. Our team has co-authored key publications in the field, including Recommendations for Method Development and Validation of qPCR and dPCR Assays in Support of Cell and Gene Therapy Drug Development (AAPS J. 2024) and The MIQE Guidelines for qPCR and dPCR.
Flexible, client-centered solutions
We work closely with our clients to find tailored solutions, offering flexibility in sample types, test items, sample volume, and scalability. We prioritize transparency and proactive communication throughout each project, ensuring our clients are continuously updated on the progress.
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Let's explore how we can support your drug development program
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