
Protein Biomarkers
Olink proteomics for drug development
At TATAA Biocenter, we have a dedicated Olink team and automated instrumentation for high-throughput Olink proteomics. We have been a service provider for Olink for over ten years and have extensive experience with various types of samples, platforms, and panels.
TATAA Biocenter is a GLP-accredited laboratory, and the Olink workflow includes our standard sample management processes and IT security measures, ensuring the same high standards as those of our regulated projects.
Thousands of data points from each microliter of sample
Validated protein biomarker panels for drug development
With only microliters of sample, hundreds to thousands of proteins can be quantified from blood in a fast, semi-automated workflow, requiring minimal hands-on time. The Olink protein biomarker panels are thoroughly validated for various performance parameters, ensuring high-quality and reliable data. Olink’s Proximity Extension Assay (PEA) technology utilizes pairs of antibodies to detect and quantify proteins with high specificity. Oligonucleotides attached to the antibodies provide the sensitivity of qPCR or NGS for readouts.
Monitor the innate immune system
The Olink Target 48 panels are designed to provide absolute quantification of key immune biomarkers in a sample, enabling rapid and efficient monitoring of the immune response.
Identify new drug targets and evaluate therapeutic effect
Olink offers several targeted panels to help understand disease mechanisms and signaling pathways to identify new drug targets. Targeted panels are used to measure target engagement and adverse effects post-treatment.
Biomarker discovery
With the Olink Explore HT platform, 5,400+ exploratory proteins are quantified simultaneously to identify non-invasive blood biomarkers for disease onset and progression, and patient stratification.
Study translational relevance
Comparing the biomarker expression in humans and mice using the mouse exploratory panel provides insight into translational relevance and supports allometric scaling. In addition, most protein assays are compatible with NHP samples.
Data output
From sample to comprehensible data
We run assays, perform quality control on the data, process it using Olink’s software, and deliver the report and the raw data files to our customers. The data generated is reported as Normalized Protein eXpression (NPX) levels. This process allows for easy comparison across different samples and conditions. In addition, the Olink Target 48 Cytokine panels generate absolute quantified data in pg/µL.
The Olink Target 48 panels provide both absolute and relative quantification. These panels include cytokines and other immune-related proteins, making them ideal for monitoring immune responses. They are perfect for assessing desired immune reactions in vaccines and CAR-T therapies, as
The Explore HT panel contains over 5,400+ proteins, almost twice as many as the Explore 3072 panels. The sample volume for Explore HT is 2 µl, compared to 6 µl for Explore 3072. The workflow for Explore HT is four
Ever wondered what the differences are between Olink Target and Olink Explore platforms? TATAA Biocenter, an Olink service provider for over 10 years explains all. Olink Target and Olink Explore are two different platforms offered by Olink Proteomics for protein
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Olink platform and panels
The Olink Explore panels are the most comprehensive panels using next-generation sequencing (NGS) for readout. Olink Explore HT contains over 5,400+ proteins, while Olink Explore 3072 contains eight 384 sub-panels that can be run individually or simultaneously as a set.
Olink® Explore 384 Cardiometabolic
Olink® Explore 384 Cardiometabolic II
Olink® Explore 384 Inflammation
Olink® Explore 384 Inflammation II
The Olink Target 96 and Target 48 panels use qPCR for readout. Fifteen Target 96 panels are available for relative quantification, and two Target 48 Cytokine panels are available for absolute quantification.
Olink Target 96 Panels
Olink® Target 96 Cardiometabolic
Olink® Target 96 Cardiovascular II
Olink® Target 96 Cardiovascular III
Olink® Target 96 Cell Regulation
Olink® Target 96 Immune Response
Olink® Target 96 Immuno Oncology
Olink® Target 96 Neuro Exploratory
For preclinical or translational research in mice:
Olink® Target 96 Mouse exploratory