Gene expression analysis services for drug development
GLP and GCLP-compliant CRO for gene expression assay development, validation, and high-throughput analysis.
Precision gene expression services
for drug development
Gene expression profiling services
Our validated qPCR and dPCR assays and RNA-seq workflows are designed to monitor differentially expressed genes with high sensitivity, reproducibility, and scalability, supporting studies from small to large-scale preclinical and clinical trials.
GLP and GCLP compliant laboratory
We are accredited for Good Laboratory Practice (GLP) by the Swedish Board for Accreditation and Conformity Assessment (SWEDAC) for qPCR, dPCR, and molecular biology. In addition, we are Good Clinical Laboratory Practice (GCLP) compliant to ensure the safe and reliable analysis of clinical samples.
Gene expression analysis at TATAA
Samples
- Tissues
- Liquid biopsies
- Fresh frozen
- FFPE
- EDTA
- PAXgene tubes
Analytes
- Total RNA
- mRNA
- miRNA
- siRNA
- gRNA
- ASOs
Variability in RNA quality, method sensitivity limitations, and the need for precise quantification present challenges in mRNA expression analysis. dPCR gene expression analysis and real-time qPCR provide absolute quantification with high sensitivity, enabling the detection of low-abundance transcripts, including AAV gene expression. Transcriptomic approaches monitor large-scale transcriptional changes across diverse pathways.
Our high-throughput workflows ensure efficient processing of large sample sets, generating reproducible RNA expression data that support biomarker discovery and therapeutic monitoring.
AAV gene expression (transgene expression levels), transient expression in gene therapy, potential drug-inhibiting gene expression in gene silencing therapies, and the expression of PD biomarkers and immune genes can impact drug efficacy and dosing strategies.
We develop and optimize methods and quantify gene expression, whether for absolute quantification of low-copy transgene expression or detecting pathway changes related to intended or unintended events.
qPCR and dPCR provide sensitive, high-precision targeted analysis. Multiplex gene expression analysis and RNA-Seq-based techniques enable higher resolution and offer a comprehensive overview of gene expression changes across different conditions. We design our assays for low-copy targets, such as AAV transgene expression, circulating tumor cell gene expression, and biofluid-based biomarker workflows to deliver exceptional sensitivity, reproducibility, and scalability required for large-scale studies.
Resources
Overview of bioanalysis in advanced therapies
- Assay design and validation
- Regulatory guidelines (EMA and FDA)
- Challenges and best practices
Genomic biomarker analysis (DNA, RNA, miRNA, ctDNA etc,)
- Technology overview
- Analytical validation
- Regulatory overview
Capability PDF
Download our latest brochure for a summary of our molecular CRO services and capabilities.