Targeted NGS sequencing service
Targeted next-generation sequencing (NGS) enriches specific genomic regions for deeper sequencing coverage, enabling the detection of rare variants.
Targeted NGS services at TATAA
The targeted panels are customized to focus on disease-related genes or drug response pathways, using various biological samples based on your specific needs.
- Identify mutations in key genes linked to specific diseases.
- Detect actionable mutations for treatment response and disease progression.
- Group patients based on mutations in selected therapeutic genes.
- Detect known resistance mutations during treatment for timely intervention.
- Identify mutations associated with adverse drug reactions or toxicity.
- Investigate known disease-causing mutations in patient populations.
Targeted panels allow you to sequence only the specific regions of interest.
| Whole genome sequencing | Whole exome sequencing | Targeted Gene Panels | Circulating Tumor DNA (ctDNA) | |
| Library preparation | IDT xGen DNA Library Prep Kit EZ with UDIs | IDT xGen DNA Library Prep Kit EZ with UDIs, combined with xGen Exome Hyb Panel v2 | ||
| Recommended sample input | Fresh frozen cells or tissue EDTA whole blood or PAXgene DNA tubes High quality FFPE (IDT DNA Integrity score > 1.0) |
Fresh frozen cells or tissue EDTA whole blood or PAXgene DNA tubes High quality FFPE (IDT DNA Integrity score > 1.0) |
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| Recommended DNA input | Range: 0.1 ng – 1 ug Standard input: 100ng |
Range: 0.1 ng – 1 ug Standard input: 100ng |
Range: 0.1 ng – 1 ug Standard input: 100ng |
Range: 0.1 ng – 1 ug Standard input: 100ng |
| Recommended sequencing | Paired-end sequencing | Paired-end sequencing | Paired-end sequencing | Paired-end sequencing |
| Deliverables | Quality-controlled data Fastq files Study report |
Quality-controlled data Fastq files Study report |
Quality-controlled data Fastq files Study report |
Quality-controlled data Fastq files Study report |
GLP and GCLP compliant laboratory
We are accredited for Good Laboratory Practice (GLP) by the Swedish Board for Accreditation and Conformity Assessment (SWEDAC) for qPCR, dPCR, and molecular biology. In addition, we are Good Clinical Laboratory Practice (GCLP) compliant to ensure the safe and reliable analysis of clinical samples.
Resources
Overview of bioanalysis in advanced therapies
- Assay design and validation
- Regulatory guidelines (EMA and FDA)
- Challenges and best practices
Genomic biomarker analysis (DNA, RNA, miRNA, ctDNA etc,)
- Technology overview
- Analytical validation
- Regulatory overview
Capability PDF
Download our latest brochure for a summary of our molecular CRO services and capabilities.