Technologies → DNA-Seq → Whole genome sequencing

Whole genome sequencing service

Optimized and automated next-generation sequencing (NGS) workflows to provide whole genome sequencing (WGS) services for drug development, from discovery to clinical trials.

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WGS services at TATAA

Whole genome sequencing (WGS) determines an individual’s complete DNA sequence in a single process, offering a comprehensive view of their genetic makeup. It enables the detection of single nucleotide variants (SNVs), insertions and deletions (indels), copy number variations (CNVs), and structural variants (SVs).

Identify mutations and pathways for new drug targets.
Discover genetic markers for treatment response and disease progression.
Detect genetic variants affecting drug metabolism and resistance.
Stratify patients to therapies based on genetic profiles.
Detect genetic risk for adverse drug reactions or toxicity.
Track tumor evolution and clonal heterogeneity for therapy adaptation.
Identify mutations for orphan drug and gene therapy development.

Whole genome sequencing (WGS) analyzes both coding exons and non-coding introns.

	Whole genome sequencing	Whole exome sequencing	Targeted Gene Panels	Circulating Tumor DNA (ctDNA)
Library preparation	IDT xGen DNA Library Prep Kit EZ with UDIs	IDT xGen DNA Library Prep Kit EZ with UDIs, combined with xGen Exome Hyb Panel v2
Recommended sample input	Fresh frozen cells or tissue EDTA whole blood or PAXgene DNA tubes High quality FFPE (IDT DNA Integrity score > 1.0)	Fresh frozen cells or tissue EDTA whole blood or PAXgene DNA tubes High quality FFPE (IDT DNA Integrity score > 1.0)
Recommended DNA input	Range: 0.1 ng – 1 ug Standard input: 100ng	Range: 0.1 ng – 1 ug Standard input: 100ng	Range: 0.1 ng – 1 ug Standard input: 100ng	Range: 0.1 ng – 1 ug Standard input: 100ng
Recommended sequencing	Paired-end sequencing	Paired-end sequencing	Paired-end sequencing	Paired-end sequencing
Deliverables	Quality-controlled data Fastq files Study report	Quality-controlled data Fastq files Study report	Quality-controlled data Fastq files Study report	Quality-controlled data Fastq files Study report

DNA-seq services

GLP and GCLP compliant laboratory

We are accredited for Good Laboratory Practice (GLP) by the Swedish Board for Accreditation and Conformity Assessment (SWEDAC) for qPCR, dPCR, and molecular biology. In addition, we are Good Clinical Laboratory Practice (GCLP) compliant to ensure the safe and reliable analysis of clinical samples.