Genomic biomarkers
Introducing genomic biomarker analysis
A biomarker is an objectively measurable factor that can indicate disease risk, predict treat...
qPCR, dPCR, and NGS for siRNA bioanalysis
Quantitative PCR (qPCR), digital PCR (dPCR), and Next-Generation Sequencing (NGS) are essential technologies in siRNA bioanalysis. They...
Precision bioanalysis for advanced therapies
Method development and validation of regulatory qPCR and dPCR assays for biodistribution, viral shedding, and pharmacokinetics in gene ...
TCR/BCR sequencing and dPCR for CAR-T safety monitoring
Immunosequencing entails the high-throughput sequencing of T-cell (TCR) and B-cell receptors (BCR), offering invaluable insights into t...
RNA extraction from PAXgene tubes
Controlling and optimizing steps in extracting RNA from PAXgene tubes significantly improves yield and quality and can lead to more acc...
Replication competent lentivirus testing
Ensuring biosafety in cell therapies: Replication Competent Lentivirus Testing (RCL) with digital PCR
Why Replication Competent Lentiv...
IncRNA: From junk to a therapeutic goldmine
Not long ago, much of the genome that doesn’t encode proteins was dismissed as junk DNA. But science has made it abundantly clear that ...
Viral Vector Characterization and Integrity Testing
Viral vector characterization is the comprehensive analytical process used to evaluate the quality, identity, purity, potency, and safe...
Vector Copy Number Analysis
Balancing efficacy and safety through VCN analysis
Vector copy number is all about balancing efficacy against safety. More copies will...
qPCR Primer Design
This guide discusses strategies for designing qPCR assays, including primers and probes, for bioanalysis in cell and gene therapies.qPC...